Mo Welch is a stand up comedian and cartoonist. She appeared on CONAN in January of 2018 and in February of 2019. Her 10 part animated series BLAIR debuted on TBS Digital in January 2018. Her comics have been published in The New Yorker, Cosmopolitan Magazine, Vice, and more. She starred in Foul Ball on CBS, Hulu's Coming To The Stage and appears in season 2 of Amazon's Gortimer Gibbon's Life on Normal Street, season two of Life in Pieces on CBS, and season 2 of Corporate on Comedy Central.  She was named an Up Next Comedian by Comedy Central in 2017 and a Comic to Watch by TimeOut in 2019. She has worked as a writer for Nickelodeon, TBS and CBS.

Her book How to Die Alone will be available for purchase on April 16, 2019. A book tour will follow.

The Chicago Reader called her "Hysterically Brilliant" and Splitsider calls her "impossibly cool". Along with her comics, she was featured on Buzzfeed, The A.V. Club, Serial Optimist, and LA Weekly.